Article
Abnormalities in the p53 gene in tumors and cell lines of human squamous-cell carcinomas of the head and neck.
International journal of cancer - 8 May 1993
Yin X Y, Smith M L, Whiteside T L, Johnson J T, Herberman R B, Locker J
Abstract excerpt
Abnormalities in the p53 gene were studied in a series of cell lines of human squamous-cell carcinoma of the head and neck (SCCHN) and in tumor tissues. Restriction-fragment-length polymorphism (RFLP), quantitative hybridization and immunochemical analysis of mutant p53 proteins were combined to...
Topics
- Alleles
- Carcinoma, Squamous Cell
- Chromosome Aberrations
- Chromosome Deletion
- Chromosome Disorders
- Chromosomes, Human, Pair 17
- DNA, Neoplasm
- Genes, p53
- Head and Neck Neoplasms
- Humans
- Nucleic Acid Hybridization
- Polymorphism, Restriction Fragment Length
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53