Article
The incidence of p53 mutations increases with progression of head and neck cancer.
Cancer research - 1 Oct 1993
Boyle J O, Hakim J, Koch W, van der Riet P, Hruban R H, Roa R A, Correo R, Eby Y J, Ruppert J M, Sidransky D
Abstract excerpt
To establish a genetic model of the progression of head and neck squamous carcinoma we have defined the incidence and timing of p53 mutations in this type of cancer. We sequenced the conserved regions of the p53 gene in 102 head and neck squamous carcinoma lesions. These included 65 primary invasive carcinomas and 37 noninvasive archival specimens consisting of 13 severe dysplasias and 24 carcinoma in situ...
Topics
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- Carcinoma
- Carcinoma in Situ
- Cloning, Molecular
- DNA Primers
- DNA, Neoplasm
- Exons
- Female
- Genes, p53
- Head and Neck Neoplasms
- Humans
- Male