p53 overexpression in head and neck squamous cell carcinoma: review of the literature.

doi:10.1016/0964-1955(95)00095-x

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Article

p53 overexpression in head and neck squamous cell carcinoma: review of the literature.

European journal of cancer. Part B, Oral oncology - 1 May 1996

Raybaud-Diogène H, Tétu B, Morency R, Fortin A, Monteil R A

Abstract excerpt

As a tumour suppressor gene, the inactivation of p53 induces the development of numerous human cancers. Mutations of p53 have been implicated in the pathogenesis of head and neck squamous cell carcinoma (HN-SCC) at a high incidence. In premalignant lesions and in situ carcinomas, p53 overexpressi...

Topics

Biomarkers, Tumor
Gene Expression
Head and Neck Neoplasms
Humans
Mutation
Precancerous Conditions
Tumor Suppressor Protein p53

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