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Article

p53 in head and neck cancer: Functional consequences and environmental implications of TP53mutations

1 Dec 2010

Abstract excerpt

BACKGROUND: Although TP53 mutations in human tumours generally have been extensively studied, the significance of p53 in the aetiology of head and neck cancers is still incompletely characterized. In recent years, considerable interest has been focused on mutant forms of p53, the abnormal protein product of TP53 alleles with missense mutation that often accumulate in cancer cells. METHODS: We compared the nature...

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PMID: 21159183
DOI: 10.1186/1758-3284-2-36

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