p53 mutations in human head and neck cancer cell lines.

doi:10.3109/00016489709124132

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Article

p53 mutations in human head and neck cancer cell lines.

Acta oto-laryngologica. Supplementum - 1 Jan 1997

Kiuru A, Servomaa K, Grénman R, Pulkkinen J, Rytömaa T

Abstract excerpt

The p53 tumour suppressor gene is commonly mutated in human cancers. We performed a molecular analysis of the frequency and spectrum of p53 gene mutations in 40 cell lines (23 from oral cavity tumours and 17 from larynx tumours) derived from 33 patients with squamous cell carcinoma of the head an...

Topics

Carcinoma, Squamous Cell
DNA, Neoplasm
Genes, p53
Head and Neck Neoplasms
Humans
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Sequence Analysis, DNA
Tumor Cells, Cultured

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