Article
Homozygosity of the short arm of chromosome 17 in cervical carcinoma.
Cancer letters - 30 Apr 1992
Russell S E, Lowry W S, Atkinson R J, Hickey I
Abstract excerpt
We have determined the frequency of heterozygosity of the short arm of chromosome 17 in 20 cervical tumours using the highly polymorphic probe pYNZ22. Only 25% of the tumours were heterozygous at this locus. This is significantly lower than the level of 86% heterozygosity for this locus in the general population indicating that loss of one allele occurs in cervical cancer. Heterozygosity for a locus on the long...
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