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Article

Evidence implicating at least two genes on chromosome 17p in breast carcinogenesis.

Lancet (London, England) - 29 Sept 1990

Coles C, Thompson A M, Elder P A, Cohen B B, Mackenzie I M, Cranston G, Chetty U, Mackay J, Macdonald M, Nakamura Y

Abstract excerpt

The DNA of paired tumour and blood leucocyte samples from a large series of breast cancer patients was analysed to map regions of loss of heterozygosity on chromosome 17. The high frequency of loss of heterozygosity on 17p was confirmed, and a third of informative tumours had also lost an allele at the long arm locus THH59. On the short arm two distinct regions of loss of heterozygosity were identified, in bands...

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Identifiers

PMID: 1976143
DOI: 10.1016/0140-6736(90)93236-i

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence implicating at least two genes on chromosome 17p in breast carcinogenesis.PMID 1976143Read ↗

Genetic alterations of the tumour suppressor gene regions 3p, 11p, 13q, 17p, and 17q in human breast carcinomas.Semantic proximity Read ↗

Evidence for a gene on 17p13.3, distal to TP53, as a target for allele loss in breast tumors without p53 mutations.Semantic proximity Read ↗

p53 allele losses, mutations and expression in breast cancer and their relationship to clinico-pathological parameters.Semantic proximity Read ↗

Four separate regions on chromosome 17 show loss of heterozygosity in familial breast carcinomas.Semantic proximity Read ↗

Deletion of 17p in cancers: Guilt by (p53) associationSemantic proximity Read ↗

Prognostic significance of loss of heterozygosity at loci on chromosome 17p13.3-ter in sporadic breast cancer is evidence for a putative tumour suppressor gene.Semantic proximity Read ↗

Loss of heterozygosity at selective sites on chromosomes 13 and 17 in human breast carcinoma.Semantic proximity Read ↗

Evidence for a second tumor suppressor gene on 17p linked to high S-phase index in primary human breast carcinomas.Semantic proximity Read ↗

Loss of chromosome 17p13 sequences and mutation of p53 in human breast carcinomas.Semantic proximity Read ↗

Allelic loss at BRCA1, BRCA2, and adjacent loci in relation to TP53 abnormality in breast cancer.Semantic proximity Read ↗

Allelic imbalance at chromosome 17p13.3 (YNZ22) in breast cancer is independent of p53 mutation or p53 overexpression and is associated with poor prognosis at medium-term follow-up.Semantic proximity Read ↗

Allele loss patterns on chromosome 17q in 109 breast carcinomas indicate at least two distinct target regions.Semantic proximity Read ↗

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