Article
Evidence implicating at least two genes on chromosome 17p in breast carcinogenesis.
Lancet (London, England) - 29 Sept 1990
Coles C, Thompson A M, Elder P A, Cohen B B, Mackenzie I M, Cranston G, Chetty U, Mackay J, Macdonald M, Nakamura Y
Abstract excerpt
The DNA of paired tumour and blood leucocyte samples from a large series of breast cancer patients was analysed to map regions of loss of heterozygosity on chromosome 17. The high frequency of loss of heterozygosity on 17p was confirmed, and a third of informative tumours had also lost an allele at the long arm locus THH59. On the short arm two distinct regions of loss of heterozygosity were identified, in bands...
Topics
- Alleles
- Breast Neoplasms
- Carcinoma
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- DNA Probes
- DNA, Neoplasm
- Female
- Gene Expression Regulation, Neoplastic
- Heterozygote