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Article

Four separate regions on chromosome 17 show loss of heterozygosity in familial breast carcinomas.

Human genetics - 1 Mar 1993

Lindblom A, Skoog L, Andersen T I, Rotstein S, Nordenskjöld M, Larsson C

Abstract excerpt

Two genes predisposing females to autosomal dominant breast cancer are located on chromosome 17. Mutations in the p53-gene on the short arm have been shown to predispose females to early onset breast cancer in families with the rare Li-Fraumeni syndrome. Another locus on 17q (BRCA1), was found to be linked to the disease in a subset of families with breast cancer. In order to determine the involvement of tumour...

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Source

Identifiers

PMID: 8454289
DOI: 10.1007/BF00230213

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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