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Article

Loss of heterozygosity on the short arm of chromosome 17 in human astrocytomas.

Neurological research - 1 Mar 1992

Wu J K, Darras B T

Abstract excerpt

Using restriction fragment length polymorphism (RFLP) analysis, we demonstrated in 4 of 20 patients with astrocytomas loss of heterozygosity on the short arm of chromosome 17 (17p), in the telomeric segment distal to DNA marker pEW301 (locus D17S58). The loss of heterozygosity may uncover a mutation in a tumour suppressor gene and thus lead to or permit tumour formation. The p53 tumour suppressor gene, which is...

Topics

Adult
Alleles
Astrocytoma
Brain Neoplasms
Cell Separation
Child
Chromosome Deletion
Chromosomes, Human, Pair 17
Genes, Tumor Suppressor
Glioblastoma
Heterozygote
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukocytes

Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 1351257
DOI: 10.1080/01616412.1992.11740008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1351257-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Loss of heterozygosity on the short arm of chromosome 17 in human astrocytomas.PMID 1351257Read ↗

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