Allele loss patterns on chromosome 17q in 109 breast carcinomas indicate at least two distinct target regions.

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Article

Allele loss patterns on chromosome 17q in 109 breast carcinomas indicate at least two distinct target regions.

Oncogene - 1 Mar 1993

Cornelis R S, Devilee P, van Vliet M, Kuipers-Dijkshoorn N, Kersenmaeker A, Bardoel A, Khan P M, Cornelisse C J

Abstract excerpt

Loss of heterozygosity (LOH) of markers for chromosome 17 is the most frequent genetic change observed in breast cancer to date. To assess whether the location of several candidate target genes is compatible with patterns of allele losses in the individual tumors, we examined the LOH status of chromosome 17 in 109 primary breast tumors with 15 polymorphic DNA markers (three for 17p and 12 for 17q). Allelic...

Topics

Alleles
Base Sequence
Breast Neoplasms
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 17
Female
Genetic Markers
Humans
Molecular Sequence Data

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Open in PubMed

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PMID: 8437862

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