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Article

Allelic loss on a chromosome 17 in ductal carcinoma in situ of the breast.

Cancer research - 1 Jul 1993

Radford D M, Fair K, Thompson A M, Ritter J H, Holt M, Steinbrueck T, Wallace M, Wells S A, Donis-Keller H R

Abstract excerpt

Multiple tumor suppressor genes are implicated in the oncogenesis and progression of invasive carcinoma of the breast. To investigate the chronology of genetic changes we studied loss of heterozygosity on chromosome 17 in ductal carcinoma in situ, a preinvasive breast cancer. A microdissection technique was used to separate tumor from normal stromal cells prior to DNA extraction and loss of heterozygosity was...

Topics

Alleles
Breast Neoplasms
Carcinoma in Situ
Carcinoma, Intraductal, Noninfiltrating
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 17
DNA, Neoplasm
Female
Genes, p53
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mutation

Source

Identifiers

PMID: 8391383

Provenance

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Allelic loss on a chromosome 17 in ductal carcinoma in situ of the breast.PMID 8391383Read ↗

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