Article
Loss of heterozygosity on the short arm of chromosome 17 is associated with high proliferative capacity and DNA aneuploidy in primary human breast cancer.
Proceedings of the National Academy of Sciences of the United States of America - 1 May 1991
Chen L C, Neubauer A, Kurisu W, Waldman F M, Ljung B M, Goodson W, Goldman E S, Moore D, Balazs M, Liu E
Abstract excerpt
Loss of heterozygosity (LOH) on the short arm of chromosome 17 (17p) was found in 27 of 52 (52%) previously untreated primary breast cancers. There was a significant correlation between this 17p allelic loss and two parameters associated with aggressive tumor behavior: high cellular proliferative fraction and DNA aneuploidy. These correlations with high cellular proliferative fraction and DNA aneuploidy were not...
Topics
- Base Sequence
- Breast Neoplasms
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- DNA Replication
- Heterozygote
- Humans
- Molecular Sequence Data
- Mutation
- Oligonucleotides