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Article

Why are there so few key mutant clones? The influence of stochastic selection and blocking on affinity maturation in the germinal center.

International immunology - 1 Jul 2003

Kleinstein Steven H, Singh Jaswinder Pal

Abstract excerpt

A small number of key somatic mutations lead to high-affinity binding in the anti-hapten immune responses to 2-phenyl-5-oxazolone (phOx) and (4-hydroxy-3-nitrophenyl)acetyl (NP). Affinity maturation models of the germinal center hold that B cells carrying these key mutations are preferentially selected for expansion within the germinal centers. However, additional factors are required to account for some...

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Source

Identifiers

PMID: 12807826
DOI: 10.1093/intimm/dxg085.sgm

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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