Predicted and inferred waiting times for key mutations in the germinal centre reaction: evidence for stochasticity in selection.

doi:10.1046/j.1440-1711.1998.00753.x

Back to search

Article

Predicted and inferred waiting times for key mutations in the germinal centre reaction: evidence for stochasticity in selection.

Immunology and cell biology - 1 Aug 1998

Radmacher M D, Kelsoe G, Kepler T B

Abstract excerpt

The germinal centre reaction (GCR) is a fundamental component of the immune response to T-dependent antigens, during which the immunoglobulin (Ig) genes of B cells experience somatic hypermutation and selection. A maximum-likelihood method on DNA sequence data from 16 individual germinal centres...

Topics

Animals
Cell Differentiation
Germinal Center
Humans
Mutation
Stochastic Processes
Time Factors

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.