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Article

Predicted and inferred waiting times for key mutations in the germinal centre reaction: evidence for stochasticity in selection.

Immunology and cell biology - 1 Aug 1998

Radmacher M D, Kelsoe G, Kepler T B

Abstract excerpt

The germinal centre reaction (GCR) is a fundamental component of the immune response to T-dependent antigens, during which the immunoglobulin (Ig) genes of B cells experience somatic hypermutation and selection. A maximum-likelihood method on DNA sequence data from 16 individual germinal centres was used to infer that the waiting time for position 33 key (high-affinity) mutations in the...

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PMID: 9723780
DOI: 10.1046/j.1440-1711.1998.00753.x

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