Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers

Abstract excerpt

Somatic hypermutation of immunoglobulin sequences in germinal center (GC) reactions must be optimized to elicit high-affinity, protective antibodies after vaccination. We expose natural killer (NK) cells as robust negative regulators of somatic hypermutation in antigen-reactive B cells. NK cells restrict follicular helper T cell (T FH ) and GC B cell frequencies and titers of antigen-specific immunoglobulin after...

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