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Article

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone.

Nature - 1 Jan 2000

Griffiths G M, Berek C, Kaartinen M, Milstein C

Abstract excerpt

Studies on the development of the immune response suggest that the repertoire of expressed antibody specificities is strongly influenced by antigen (reviewed in ref. 1). One way in which this influence is manifested is by a progressive increase in the affinity of antibody for antigen with time after immunization. This phenomenon, termed the 'maturation' of the immune response, must be due to a change in the...

Topics

Animals
Antibody Affinity
Antibody Diversity
Hybridomas
Immunoglobulin Variable Region
Mice
Mutation
Oxazoles
Oxazolone
Time Factors

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 6504141
DOI: 10.1038/312271a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6504141-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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