Article
Antigen-driven B cell differentiation in vivo.
The Journal of experimental medicine - 1 Jul 1993
McHeyzer-Williams M G, McLean M J, Lalor P A, Nossal G J
Abstract excerpt
The secretion of specific antibodies and the development of somatically mutated memory B cells in germinal centers are consequences of T cell-dependent challenge with the hapten (4-hydroxy-3-nitrophenyl)acetyl (NP). Using six-parameter flow cytometry and single cell molecular analysis we can dire...
Topics
- Amino Acid Sequence
- Animals
- Antibody-Producing Cells
- Antigens
- B-Lymphocytes
- Base Sequence
- Cell Differentiation
- Cells, Cultured
- Female
- Genes, Immunoglobulin
- Immunization
- Immunoglobulin Variable Region
- Immunologic Memory
- Male
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Mutation