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Article

Affinity maturation of B cells involves not only a few but a whole spectrum of relevant mutations.

International immunology - 1 May 2011

Weiser Armin A, Wittenbrink Nicole, Zhang Lei, Schmelzer Andrej I, Valai Atijeh, Or-Guil Michal

Abstract excerpt

Affinity maturation of B lymphocytes within germinal centers involves both diversification of their B-cell receptors (BCRs) by somatic hypermutation (SHM) and a crucial receptor-mediated selection step. However, in contrast to recent advances in revealing the molecular mechanism of SHM, the fundamentals of the selection process are still poorly understood, i.e. it is often not clear how and how many mutations...

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PMID: 21521882
DOI: 10.1093/intimm/dxr018

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BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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