Article
A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2016
Cui Ang, Di Niro Roberto, Vander Heiden Jason A, Briggs Adrian W, Adams Kris, Gilbert Tamara, O'Connor Kevin C, Vigneault Francois, Shlomchik Mark J, Kleinstein Steven H
Abstract excerpt
Analyses of somatic hypermutation (SHM) patterns in B cell Ig sequences have important basic science and clinical applications, but they are often confounded by the intrinsic biases of SHM targeting on specific DNA motifs (i.e., hot and cold spots). Modeling these biases has been hindered by the difficulty in identifying mutated Ig sequences in vivo in the absence of selection pressures, which skew the observed...
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