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Article

Ig VH hypermutation is absent in the germinal centers of aged mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 1995

Miller C, Kelsoe G

Abstract excerpt

After injection with immunogenic conjugates of the hapten (4-hydroxy-3-nitrophenyl)acetyl (NP), two distinct B cell populations can be identified in the spleen during the primary response. One of these populations is specialized for Ab production; the other, the germinal centers (GCs), has been i...

Topics

Age Factors
Animals
Antigen Presentation
B-Lymphocytes
Base Sequence
Clone Cells
Female
Immunity
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Mice
Mice, Inbred C57BL
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nitrophenols

Phenylacetates

Spleen

Source

Identifiers

PMID: 7561032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7561032-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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