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Article

Ig VH hypermutation is absent in the germinal centers of aged mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 1995

Miller C, Kelsoe G

Abstract excerpt

After injection with immunogenic conjugates of the hapten (4-hydroxy-3-nitrophenyl)acetyl (NP), two distinct B cell populations can be identified in the spleen during the primary response. One of these populations is specialized for Ab production; the other, the germinal centers (GCs), has been identified as the site of Ig somatic hypermutation. Ag-driven selection of GC B cells bearing mutated receptors with...

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PMID: 7561032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Ig VH hypermutation is absent in the germinal centers of aged mice.PMID 7561032Read ↗

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