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Article

Low antigen dose favours selection of somatic mutants with hallmarks of antibody affinity maturation.

Immunology - 1 Feb 1998

González-Fernández A, Milstein C

Abstract excerpt

The immunization schedule is critical for the derivation of high-affinity antibodies, low antigen dose being particularly favourable for the development of a more efficient memory response. To analyse the molecular events underpinning this preference, we analysed the early maturation of the response to the hapten 2-phenyloxazolone (phOx) using low and high doses of immunogen. The phOx response is initially...

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Identifiers

PMID: 9616362
DOI: 10.1046/j.1365-2567.1998.00423.x
PMCID: PMC1364172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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