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Article

Development of antibody diversity in single germinal centers: selective expansion of high-affinity variants.

European journal of immunology - 1 Oct 1994

Ziegner M, Steinhauser G, Berek C

Abstract excerpt

In a T cell-dependent immune response the microenvironment of the germinal center plays a crucial role in the affinity maturation of the antigen-specific, immunoglobulins. In order to look at the development of antibody diversity we have isolated single germinal centers and sequenced light chains characteristic of 2-phenyl-oxazolone (phOx)-specific antibodies. Fourteen days after immunization we can demonstrate...

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Identifiers

PMID: 7925566
DOI: 10.1002/eji.1830241020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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