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Article

Somatic mutations in antibodies expressed by germinal centre B cells early after primary immunization.

International immunology - 1 Jan 1990

Apel M, Berek C

Abstract excerpt

We have studied the maturation of the immune response by looking at the generation of antibody diversity in germinal centre B cells. Mice were immunized with the antigen 2-phenyloxazolone. Germinal centre B cells, defined by their strong binding to peanut agglutinin (PNA(hi], were sorted from the spleen and fused. Ten days after immunization high numbers of antigen specific hybridoma lines were obtained from the...

Topics

Animals
Antibodies
Antibody Diversity
Antigens
B-Lymphocytes
Hybridomas
Immunization
Mice
Mutation
Oxazolone

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2279001
DOI: 10.1093/intimm/2.9.813

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2279001-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Somatic mutations in antibodies expressed by germinal centre B cells early after primary immunization.PMID 2279001Read ↗

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