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Article

Somatic mutations in antibodies expressed by germinal centre B cells early after primary immunization.

International immunology - 1 Jan 1990

Apel M, Berek C

Abstract excerpt

We have studied the maturation of the immune response by looking at the generation of antibody diversity in germinal centre B cells. Mice were immunized with the antigen 2-phenyloxazolone. Germinal centre B cells, defined by their strong binding to peanut agglutinin (PNA(hi], were sorted from the spleen and fused. Ten days after immunization high numbers of antigen specific hybridoma lines were obtained from the...

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Source

Identifiers

PMID: 2279001
DOI: 10.1093/intimm/2.9.813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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