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Article

Waiting times to appearance and dominance of advantageous mutants: estimation based on the likelihood.

Mathematical biosciences - 1 Mar 2001

Radmacher M D, Kepler T B

Abstract excerpt

The germinal center reaction (GCR) of vertebrate immunity provides a remarkable example of evolutionary succession, in which an advantageous phenotype arises as a spontaneous mutation from the parental type and eventually displaces the parental type altogether. In the case of the immune response to the hapten (4-hydroxy-3-nitrophenyl)acetyl (NP), as with several other designed immunogens, the process is dominated...

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Identifiers

PMID: 11259803
DOI: 10.1016/s0025-5564(00)00064-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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