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Article

A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain.

American journal of human genetics - 1 Jul 2003

Bray Nicholas J, Buckland Paul R, Williams Nigel M, Williams Hywel J, Norton Nadine, Owen Michael J, O'Donovan Michael C

Abstract excerpt

The gene encoding catechol-O-methyltransferase (COMT) is a strong candidate for schizophrenia susceptibility, owing to the role of COMT in dopamine metabolism, and the location of the gene within the deleted region in velocardiofacial syndrome, a disorder associated with high rates of schizophrenia. Recently, a highly significant association was reported between schizophrenia and a COMT haplotype in a large...

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Source

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Identifiers

PMID: 12802784
DOI: 10.1086/376578
PMCID: PMC1180576

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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