COMT: a common susceptibility gene in bipolar disorder and schizophrenia.

doi:10.1002/ajmg.b.30032

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Article

COMT: a common susceptibility gene in bipolar disorder and schizophrenia.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jul 2004

Shifman Sagiv, Bronstein Michal, Sternfeld Meira, Pisanté Anne, Weizman Avraham, Reznik Ilya, Spivak Baruch, Grisaru Nimrod, Karp Leon, Schiffer Richard, Kotler Moshe, Strous Rael D, Swartz-Vanetik Marnina, Knobler Haim Y, Shinar Eilat, Yakir Benjamin, Zak Naomi B, Darvasi Ariel

Abstract excerpt

A variety of psychiatric illnesses, including schizophrenia and bipolar disorder, have been reported in patients with microdeletion on chromosome 22q11-a region which includes the catechol-O-methyltransferase (COMT) gene. The variety of psychiatric manifestations in patients with the 22q11 microdeletion and the role of COMT in the degradation of catecholamine neurotransmitters may thus suggest a general...

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PMID: 15211633
DOI: 10.1002/ajmg.b.30032

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COMT

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HapMap tag-SNP analysis confirms a role for COMT in schizophrenia risk and reveals a novel association.Semantic proximity Read ↗

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