HapMap tag-SNP analysis confirms a role for COMT in schizophrenia risk and reveals a novel association.

doi:10.1016/j.eurpsy.2010.08.004

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Article

HapMap tag-SNP analysis confirms a role for COMT in schizophrenia risk and reveals a novel association.

European psychiatry : the journal of the Association of European Psychiatrists - 1 Jul 2012

Voisey J, Swagell C D, Hughes I P, Lawford B R, Young R M, Morris C P

Abstract excerpt

Catechol-O-methyl transferase (COMT) encodes an enzyme involved in the metabolism of dopamine and maps to a commonly deleted region that increases schizophrenia risk. A non-synonymous polymorphism (rs4680) in COMT has been previously found to be associated with schizophrenia and results in altered activity levels of COMT. Using a haplotype block-based gene-tagging approach we conducted an association study of...

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PMID: 20934310
DOI: 10.1016/j.eurpsy.2010.08.004

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COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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