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Article

COMT haplotypes suggest P2 promoter region relevance for schizophrenia.

Molecular psychiatry - 1 Sept 2004

Palmatier M A, Pakstis A J, Speed W, Paschou P, Goldman D, Odunsi A, Okonofua F, Kajuna S, Karoma N, Kungulilo S, Grigorenko E, Zhukova O V, Bonne-Tamir B, Lu R-B, Parnas J, Kidd J R, DeMille M M C, Kidd K K

Abstract excerpt

A recent study found, in a large sample of Ashkenazi Jews, a highly significant association between schizophrenia and a particular haplotype of three polymorphic sites in the catechol-O-methyl transferase, COMT, gene: an IVS 1 SNP (dbSNP rs737865), the exon 4 functional SNP (Val158Met, dbSNP rs16...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catechol O-Methyltransferase

Share to Databases, Genetic

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Share to Linkage Disequilibrium

Share to Promoter Regions, Genetic

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Source

Identifiers

PMID: 15098000
DOI: 10.1038/sj.mp.4001496

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15098000-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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COMT haplotypes suggest P2 promoter region relevance for schizophrenia.PMID 15098000Read ↗

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Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder.Semantic proximity Read ↗

Association of the 3' region of COMT with schizophrenia in Taiwan.Semantic proximity Read ↗

Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment.Semantic proximity Read ↗

COMT genotype is associated with differential expression of muscarinic M1 receptors in human cortex.Semantic proximity Read ↗

No association between schizophrenia and polymorphisms in COMT in two large samples.Semantic proximity Read ↗

Variants in the catechol-o-methyltransferase (COMT) gene are associated with schizophrenia in Irish high-density families.Semantic proximity Read ↗

Biological effects of COMT haplotypes and psychosis risk in 22q11.2 deletion syndrome.Semantic proximity Read ↗

Association studies of catechol-O-methyltransferase (COMT) gene with schizophrenia and response to antipsychotic treatment.Semantic proximity Read ↗

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Site-specific cytosine methylation in S-COMT promoter in 31 brain regions with implications for studies involving schizophrenia.Semantic proximity Read ↗

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