Article
A highly significant association between a COMT haplotype and schizophrenia.
American journal of human genetics - 1 Dec 2002
Shifman Sagiv, Bronstein Michal, Sternfeld Meira, Pisanté-Shalom Anne, Lev-Lehman Efrat, Weizman Avraham, Reznik Ilya, Spivak Baruch, Grisaru Nimrod, Karp Leon, Schiffer Richard, Kotler Moshe, Strous Rael D, Swartz-Vanetik Marnina, Knobler Haim Y, Shinar Eilat, Beckmann Jacques S, Yakir Benjamin, Risch Neil, Zak Naomi B, Darvasi Ariel
Abstract excerpt
Several lines of evidence have placed the catechol-O-methyltransferase (COMT) gene in the limelight as a candidate gene for schizophrenia. One of these is its biochemical function in metabolism of catecholamine neurotransmitters; another is the microdeletion, on chromosome 22q11, that includes the COMT gene and causes velocardiofacial syndrome, a syndrome associated with a high rate of psychosis, particularly...
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