Article
Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder.
Human molecular genetics - 1 Nov 2006
Abdolmaleky Hamid Mostafavi, Cheng Kuang-Hung, Faraone Stephen V, Wilcox Marsha, Glatt Stephen J, Gao Fangming, Smith Cassandra L, Shafa Rahim, Aeali Batol, Carnevale Julie, Pan Hongjie, Papageorgis Panagiotis, Ponte Jose F, Sivaraman Vadivelu, Tsuang Ming T, Thiagalingam Sam
Abstract excerpt
The variability in phenotypic presentations and the lack of consistency of genetic associations in mental illnesses remain a major challenge in molecular psychiatry. Recently, it has become increasingly clear that altered promoter DNA methylation could play a critical role in mediating differential regulation of genes and in facilitating short-term adaptation in response to the environment. Here, we report the...
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