Article
Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain.
American journal of human genetics - 1 Nov 2004
Chen Jingshan, Lipska Barbara K, Halim Nader, Ma Quang D, Matsumoto Mitsuyuki, Melhem Samer, Kolachana Bhaskar S, Hyde Thomas M, Herman Mary M, Apud Jose, Egan Michael F, Kleinman Joel E, Weinberger Daniel R
Abstract excerpt
Catechol-O-methyltransferase (COMT) is a key enzyme in the elimination of dopamine in the prefrontal cortex of the human brain. Genetic variation in the COMT gene (MIM 116790) has been associated with altered prefrontal cortex function and higher risk for schizophrenia, but the specific alleles and their functional implications have been controversial. We analyzed the effects of several single-nucleotide...
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