Article
Meta-analysis of association between genetic variants in COMT and schizophrenia: an update.
Schizophrenia research - 1 May 2009
Okochi Tomo, Ikeda Masashi, Kishi Taro, Kawashima Kunihiro, Kinoshita Yoko, Kitajima Tsuyoshi, Yamanouchi Yoshio, Tomita Makoto, Inada Toshiya, Ozaki Norio, Iwata Nakao
Abstract excerpt
A common functional polymorphism, Val108/158Met (rs4680), and haplotypes rs737865-rs4680-rs165599 in the Catechol-O-methyltransferase gene (COMT) have been extensively examined for association to schizophrenia; however, results of replication studies have been inconsistent. The aim of this study was to comprehensively evaluate the genetic risk of COMT for schizophrenia. First, we performed a mutation scan to...
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