Article
Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia.
Molecular psychiatry - 1 Jun 2005
Handoko H Y, Nyholt D R, Hayward N K, Nertney D A, Hannah D E, Windus L C, McCormack C M, Smith H J, Filippich C, James M R, Mowry B J
Abstract excerpt
Several lines of evidence have implicated the catechol-O-methyltransferase (COMT) gene as a candidate for schizophrenia (SZ) susceptibility, not only because it encodes a key dopamine catabolic enzyme but also because it maps to the velocardiofacial syndrome region of chromosome 22q11 which has long been associated with SZ predisposition. The interest in COMT as a candidate SZ risk factor has led to numerous...
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