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Article

Biological effects of COMT haplotypes and psychosis risk in 22q11.2 deletion syndrome.

Biological psychiatry - 1 Mar 2014

Gothelf Doron, Law Amanda J, Frisch Amos, Chen Jingshan, Zarchi Omer, Michaelovsky Elena, Ren-Patterson Renee, Lipska Barbara K, Carmel Miri, Kolachana Bhaskar, Weizman Abraham, Weinberger Daniel R

Abstract excerpt

BACKGROUND: 22q11.2 deletion syndrome (22q11.2DS) is the most common genetic syndrome associated with schizophrenia. The catechol-O-methyltransferase (COMT) gene is located in the obligatory deletion region, and possible associations between COMT variants and neuropsychiatric manifestations in 22q11.2DS have been reported. The purpose of the current study was to evaluate the effect of COMT hemizygosity and...

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Identifiers

PMID: 23992923
DOI: 10.1016/j.biopsych.2013.07.021
PMCID: PMC3872263

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Biological effects of COMT haplotypes and psychosis risk in 22q11.2 deletion syndrome.PMID 23992923Read ↗

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Further evidence for high rates of schizophrenia in 22q11.2 deletion syndrome.Semantic proximity Read ↗

COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome.Semantic proximity Read ↗

Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS.Semantic proximity Read ↗

A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain.Semantic proximity Read ↗

Neuroimaging correlates of 22q11.2 deletion syndrome: implications for schizophrenia research.Semantic proximity Read ↗

Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain.Semantic proximity Read ↗

Dopamine metabolism in adults with 22q11 deletion syndrome, with and without schizophrenia--relationship with COMT Val¹⁰⁸/¹⁵⁸Met polymorphism, gender and symptomatology.Semantic proximity Read ↗

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Effects of a functional COMT polymorphism on prefrontal cognitive function in patients with 22q11.2 deletion syndrome.Semantic proximity Read ↗

Identification of sequence variants and analysis of the role of the catechol-O-methyl-transferase gene in schizophrenia susceptibility.Semantic proximity Read ↗

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