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Article

Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine.

Proceedings of the National Academy of Sciences of the United States of America - 13 May 2003

Mattay Venkata S, Goldberg Terry E, Fera Francesco, Hariri Ahmad R, Tessitore Alessandro, Egan Michael F, Kolachana Bhaskar, Callicott Joseph H, Weinberger Daniel R

Abstract excerpt

Monamines subserve many critical roles in the brain, and monoaminergic drugs such as amphetamine have a long history in the treatment of neuropsychiatric disorders and also as a substance of abuse. The clinical effects of amphetamine are quite variable, from positive effects on mood and cognition in some individuals, to negative responses in others, perhaps related to individual variations in monaminergic...

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Identifiers

PMID: 12716966
DOI: 10.1073/pnas.0931309100
PMCID: PMC156347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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