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Article

Effect of catechol-O-methyltransferase val158met genotype on attentional control.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 18 May 2005

Blasi Giuseppe, Mattay Venkata S, Bertolino Alessandro, Elvevåg Brita, Callicott Joseph H, Das Saumitra, Kolachana Bhaskar S, Egan Michael F, Goldberg Terry E, Weinberger Daniel R

Abstract excerpt

The cingulate cortex is richly innervated by dopaminergic projections and plays a critical role in attentional control (AC). Evidence indicates that dopamine enhances the neurophysiological signal-to-noise ratio and that dopaminergic tone in the frontal cortex is critically dependent on catechol-O-methyltransferase (COMT). A functional polymorphism (val158met) in the COMT gene accounts for some of the individual...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15901785
DOI: 10.1523/JNEUROSCI.0476-05.2005
PMCID: PMC6724859

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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