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Article

Catechol-O-methyltransferase val158met genotype modulates sustained attention in both the drug-free state and in response to amphetamine.

Psychiatric genetics - 1 Jun 2010

Hamidovic Ajna, Dlugos Andrea, Palmer Abraham A, de Wit Harriet

Abstract excerpt

OBJECTIVE: Variation in the catechol-O-methyltransferase (COMT) val(158)met polymorphism has been associated with executive cognition and working memory, presumably mediated by the prefrontal cortex. Here, we extend these observations by examining two measures of cognitive function, lapses in attention and visuo-spatial-motor speed of processing, in both the drug-free state and after administration of...

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Source

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Identifiers

PMID: 20414144
DOI: 10.1097/YPG.0b013e32833a1f3c
PMCID: PMC2875066

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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