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Article

Prefrontal white matter impairment in substance users depends upon the catechol-o-methyl transferase (COMT) val158met polymorphism.

NeuroImage - 1 Apr 2013

Zhang Xiaochu, Lee Mary R, Salmeron Betty Jo, Stein Dan J, Hong L Elliot, Geng Xiujuan, Ross Thomas J, Li Nan, Hodgkinson Colin, Shen Pei-Hong, Yang Yihong, Goldman David, Stein Elliot A

Abstract excerpt

Individuals addicted to most chemical substances present with hypoactive dopaminergic systems as well as altered prefrontal white matter structure. Prefrontal dopaminergic tone is under genetic control and is influenced by and modulates descending cortico-striatal glutamatergic pathways that in turn, regulate striatal dopamine release. The catechol-O-methyltransferase (COMT) gene contains an evolutionarily recent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23219927
DOI: 10.1016/j.neuroimage.2012.11.056
PMCID: PMC9361206

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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