Article
The catechol-O-methyltransferase polymorphism: relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Nov 2004
Bilder Robert M, Volavka Jan, Lachman Herbert M, Grace Anthony A
Abstract excerpt
Diverse phenotypic associations with the catechol-O-methyltransferase (COMT) Val158Met polymorphism have been reported. We suggest that some of the complex effects of this polymorphism be understood from the perspective of the tonic-phasic dopamine (DA) hypothesis. We hypothesize that the COMT Met allele (associated with low enzyme activity) results in increased levels of tonic DA and reciprocal reductions in...
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