Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

COMT val158met moderation of dopaminergic drug effects on cognitive function: a critical review.

The pharmacogenomics journal - 1 Oct 2016

Schacht J P

Abstract excerpt

The relationship between dopamine (DA) tone in the prefrontal cortex (PFC) and PFC-dependent cognitive functions (for example, working memory, selective attention, executive function) may be described by an inverted-U-shaped function, in which both excessively high and low DA is associated with impairment. In the PFC, the COMT val158met single nucleotide polymorphism (rs4680) confers differences in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antipsychotic Agents
Share to Dopamine Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopamine Agonists

Share to Patient Selection

Share to Pharmacogenomic Variants

Share to Prefrontal Cortex

Share to Receptors, Dopamine D1

Share to Receptors, Dopamine D2

Source

Open in PubMed Open full text

Identifiers

PMID: 27241058
DOI: 10.1038/tpj.2016.43
PMCID: PMC5028240

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

COMT val158met moderation of dopaminergic drug effects on cognitive function: a critical review.PMID 27241058Read ↗

COMT Val158Met Genotype Determines the Direction of Cognitive Effects Produced by Catechol-O-Methyltransferase InhibitionSemantic proximity Read ↗

Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype.Semantic proximity Read ↗

More than an “inverted-U”? An exploratory study of the association between the catechol-o-methyltransferase gene polymorphism and executive functions in Parkinson’s diseaseSemantic proximity Read ↗

Effects of COMT polymorphisms on brain function and behavior in health and disease.Semantic proximity Read ↗

COMT val158met genotype alters the effects of methamphetamine dependence on dopamine and dopamine-related executive function: preliminary findings.Semantic proximity Read ↗

Genes, cognition and brain through a COMT lens.Semantic proximity Read ↗

Enhancing dopamine tone modulates global and local cortical perfusion as a function of COMT val158met genotype.Semantic proximity Read ↗

Association Between the COMT Val158Met Polymorphism and Antipsychotic Efficacy in Schizophrenia: An Updated Meta-Analysis.Semantic proximity Read ↗

Effect of COMT val158met genotype on cognition and personality.Semantic proximity Read ↗

Gender effects of the COMT Val 158 Met genotype on verbal fluency in healthy adults.Semantic proximity Read ↗

Treatment of cognitive deficits associated with schizophrenia: potential role of catechol-O-methyltransferase inhibitors.Semantic proximity Read ↗

Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.