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Article

COMT val158met genotype alters the effects of methamphetamine dependence on dopamine and dopamine-related executive function: preliminary findings.

Psychiatry research - 1 Oct 2020

Saloner Rowan, Cherner Mariana, Sundermann Erin E, Watson Caitlin Wei-Ming, Iudicello Jennifer E, Letendre Scott L, Kumar Adarsh, Ellis Ronald J

Abstract excerpt

The Met-allele of the COMT Val158Met polymorphism slows metabolism and increases bioavailability of dopamine (DA) in the prefrontal cortex compared to the Val-allele. Healthy Met-carriers outperform Val-carriers on executive function (EF) tests, yet this 'advantage' disappears in methamphetamine (METH) dependence. Met-carriers may be disproportionately vulnerable to METH-related perturbations of DA, yet it is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32739643
DOI: 10.1016/j.psychres.2020.113269
PMCID: PMC7530039

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