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Article

Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype.

Nature neuroscience - 1 May 2005

Meyer-Lindenberg Andreas, Kohn Philip D, Kolachana Bhaskar, Kippenhan Shane, McInerney-Leo Aideen, Nussbaum Robert, Weinberger Daniel R, Berman Karen Faith

Abstract excerpt

Using multimodal neuroimaging in humans, we demonstrate specific interactions between prefrontal activity and midbrain dopaminergic synthesis. A common V(108/158)M substitution in the gene for catecholamine-O-methyltransferase (COMT), an important enzyme regulating prefrontal dopamine turnover, predicted reduced dopamine synthesis in midbrain and qualitatively affected the interaction with prefrontal cortex....

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Source

Identifiers

PMID: 15821730
DOI: 10.1038/nn1438

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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