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Article

Does COMT genotype influence the effects of d-amphetamine on executive functioning?

Genes, brain, and behavior - 1 Feb 2013

Wardle M C, Hart A B, Palmer A A, de Wit H

Abstract excerpt

In a widely cited study, Mattay et al. reported that amphetamine (0.25 mg/kg oral, or 17 mg for a 68 kg individual) impaired behavioral and brain indices of executive functioning, measured using the Wisconsin Card Sorting Task (WCST) and N-Back working memory task, in 6 individuals homozygous for the met allele of the val158met polymorphism in the catechol-O-methyltransferase (COMT) gene, whereas it improved...

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Source

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Identifiers

PMID: 23231539
DOI: 10.1111/gbb.12012
PMCID: PMC3553317

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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