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Article

Catechol-o-methyltransferase valine(158)methionine genotype and resting regional cerebral blood flow in medication-free patients with schizophrenia.

Biological psychiatry - 1 Feb 2010

Eisenberg Daniel Paul, Sarpal Deepak, Kohn Philip D, Meyer-Lindenberg Andreas, Wint Dylan, Kolachana Bhaskar, Apud José, Weinberger Daniel R, Berman Karen Faith

Abstract excerpt

BACKGROUND: A valine(158)methionine (val(158)met) polymorphism in catechol-O-methyltransferase (COMT) modulates cortical dopaminergic catabolism and has been associated with schizophrenia. Consistent with schizophrenia itself, during cognitive tasks, the risk (val) allele predicts less efficient prefrontal cortex (PFC) physiology and worse performance, while during aversive stimuli viewing, this allele predicts...

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Identifiers

PMID: 19892319
DOI: 10.1016/j.biopsych.2009.08.039
PMCID: PMC2812618

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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