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Article

Association of abstinence-induced alterations in working memory function and COMT genotype in smokers.

Psychopharmacology - 1 Dec 2013

Ashare Rebecca L, Valdez Jeffrey N, Ruparel Kosha, Albelda Benjamin, Hopson Ryan D, Keefe John R, Loughead James, Lerman Caryn

Abstract excerpt

RATIONALE: The common methionine (met) for valine (val) at codon 158 (val(158)met) polymorphism in the catechol-O-methyltransferase (COMT) gene has been associated with nicotine dependence, alterations in executive cognitive function, and abstinence-induced working memory deficits in smokers. OBJECTIVES: We sought to replicate the association of the COMT val allele with abstinence-induced alterations in working...

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Source

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Identifiers

PMID: 23828159
DOI: 10.1007/s00213-013-3197-3
PMCID: PMC3840089

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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