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Article

The effects of catechol O-methyltransferase genotype on brain activation elicited by affective stimuli and cognitive tasks.

Reviews in the neurosciences - 1 Jan 2006

Heinz Andreas, Smolka Michael N

Abstract excerpt

Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. A functional polymorphism in the COMT gene (val158 met) accounts for a four-fold variation in enzyme activity. The low activity met158 allele has been associated with improved working memory, executive functioning, and attentional control, but also with a higher risk of anxiety-related...

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Source

Identifiers

PMID: 16878403
DOI: 10.1515/revneuro.2006.17.3.359

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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