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Article

On the conformation of the COOH-terminal domain of the large mechanosensitive channel MscL.

The Journal of general physiology - 1 Mar 2003

Anishkin Andriy, Gendel Vyacheslav, Sharifi Neda A, Chiang Chien-Sung, Shirinian Lena, Guy H Robert, Sukharev Sergei

Abstract excerpt

COOH-terminal (S3) domains are conserved within the MscL family of bacterial mechanosensitive channels, but their function remains unclear. The X-ray structure of MscL from Mycobacterium tuberculosis (TbMscL) revealed cytoplasmic domains forming a pentameric bundle (Chang, G., R.H. Spencer, A.T. Lee, M.T. Barclay, and D.C. Rees. 1998. SCIENCE: 282:2220-2226). The helices, however, have an unusual orientation in...

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Identifiers

PMID: 12601086
DOI: 10.1085/jgp.20028768
PMCID: PMC2217331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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