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Article

Disulfide trapping the mechanosensitive channel MscL into a gating-transition state.

Biophysical journal - 15 Feb 2007

Iscla Irene, Levin Gal, Wray Robin, Blount Paul

Abstract excerpt

The mechanosensitive channel of large conductance, MscL, serves as a biological emergency release valve protecting bacteria from acute osmotic downshock, and is to date the best characterized mechanosensitive channel. The N-terminal region of the protein has been shown to be critical for function by random, site-directed, and deletion mutagenesis, yet is structurally poorly understood. One model proposes that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17114217
DOI: 10.1529/biophysj.106.090316
PMCID: PMC1783893

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disulfide trapping the mechanosensitive channel MscL into a gating-transition state.PMID 17114217Read ↗

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