Article
Correlating a protein structure with function of a bacterial mechanosensitive channel.
The Journal of biological chemistry - 6 Oct 2000
Moe P C, Levin G, Blount P
Abstract excerpt
MscL, a mechanosensitive channel found in many bacteria, protects cells from hypotonic shock by reducing intracellular pressure through release of cytoplasmic osmolytes. First isolated from Escherichia coli, this protein has served as a model for how a protein senses and responds to membrane tension. Recently the structure of a functionally uncharacterized MscL homologue from Mycobacterium tuberculosis was solved...
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