Article
NOD alleles at Idd1 and Idd2 loci drive exocrine pancreatic inflammation.
Immunogenetics - 1 Dec 2024
Caron Laurence, Vdovenko Daria, Lombard-Vadnais Félix, Lesage Sylvie
Abstract excerpt
Non-obese diabetic (NOD) mice spontaneously develop autoimmune diabetes and have enabled the identification of several loci associated with diabetes susceptibility, termed insulin-dependent diabetes (Idd). The generation of congenic mice has allowed the characterization of the impact of several loci on disease susceptibility. For instance, NOD.B6-Idd1 and B6.NOD-Idd1 congenic mice were instrumental in...
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